LMO3 reprograms visceral adipocyte metabolism during obesity
نویسندگان
چکیده
منابع مشابه
Adipocyte metabolism and obesity.
Adipose tissue metabolism exerts a profound impact on whole-body metabolism. We review how fuel partitioning between adipocytes and other tissues affects insulin signaling pathways. We discuss the role of adipose tissue inflammation in adipocyte metabolism and whole-body insulin sensitivity. Finally, we mention the role of adipokines in autocrine and paracrine signaling.
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Increased visceral fat is associated with a high risk of diabetes and metabolic syndrome and is in part caused by excessive glucocorticoids (GCs). However, the molecular mechanisms remain undefined. We now identify the GC-dependent gene LIM domain only 3 (LMO3) as being selectively upregulated in a depot-specific manner in human obese visceral adipose tissue, localizing primarily in the adipocy...
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ژورنال
عنوان ژورنال: Journal of Molecular Medicine
سال: 2021
ISSN: 0946-2716,1432-1440
DOI: 10.1007/s00109-021-02089-9